Orforglipron (Foundayo) – A Second Oral GLP-1 Receptor Agonist for Weight Loss
May 25, 2026 (Issue: 1755)
The FDA has approved orforglipron (Foundayo – Lilly), an
oral small-molecule, nonpeptide glucagon-like peptide-1
(GLP-1) receptor agonist, to reduce excess body weight and
maintain weight reduction long term in adults with obesity, or
with...more
- Oral semaglutide (Wegovy) for weight loss. Med Lett Drugs Ther 2026; 68:17.
- SE Kanoski et al. GLP-1 and weight loss: unraveling the diverse neural circuitry. Am J Physiol Regul Integr Comp Physiol 2016; 310:R885. doi:10.1152/ajpregu.00520.2015
- X Ma et al. Pharmacokinetic bioequivalence of orforglipron tablets and capsules in healthy participants with obesity or overweight. Diabetes Obes Metab 2026 April 17 (epub). doi:10.1111/dom.70783
- S Wharton et al. Orforglipron, an oral small-molecule GLP-1 receptor agonist for obesity treatment. N Engl J Med 2025; 393:1796. doi:10.1056/nejmoa2511774
- DB Horn et al. Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial. Lancet 2025; 406:2927. doi:10.1016/s0140-6736(25)02165-8
- In brief: GI effects of GLP-1 receptor agonists. Med Lett Drugs Ther 2023; 65:191.
- Inhibitors and inducers of CYP enzymes, P-glycoprotein, and other transporters. Med Lett Drugs Ther 2023 January 25 (epub). Available at: www.medicalletter.org/downloads/CYP_PGP_Tables.pdf.
- Approximate WAC. WAC = wholesaler acquisition cost or manufacturer’s published price to wholesalers; WAC represents a published catalogue or list price and may not represent an actual transactional price. Source: AnalySource® Monthly.May 5, 2026. Reprinted with permission by First Databank, Inc. All rights reserved. ©2026. www.fdbhealth.com/drug-pricing-policy.
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