The Medical Letter on Drugs and Therapeutics
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ISSUE 1706
ISSUE 1706
July 8, 2024
Issue 1706
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Drugs for Postmenopausal Osteoporosis
July 8, 2024 (Issue: 1706)
Pharmacologic treatment is recommended for
postmenopausal women who have bone density
T-scores (standard deviations from normal mean
values in the spine, femoral neck, total hip, or distal
radius) of -2.5 or below, T-scores between -1.0 and
-2.5...more
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- FRAX. Fracture risk assessment tool. Available at https://bit.ly/4c0LQHJ. Accessed June 18, 2024.
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- FDA Drug Safety Communication: New contraindication and updated warning on kidney impairment for Reclast (zoledronic acid). Available at https://bit.ly/3RLTAWb. Accessed June 20, 2024.
- AA Khan et al. Case-based review of osteonecrosis of the jaw (ONJ) and application of the international recommendations for management from the International Task Force on ONJ. J Clin Densitom 2017; 20:8. doi:10.1016/j.jocd.2016.09.005
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- DM Black et al. Atypical femur fracture risk versus fragility fracture prevention with bisphosphonates. N Engl J Med 2020; 383:743. doi:10.1056/nejmoa1916525
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- DM Black et al. Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. JAMA 2006; 296:2927. doi:10.1001/jama.296.24.2927
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- KA Thal et al. Denosumab versus bisphosphonates for reducing fractures in postmenopausal women with osteoporosis: a meta-analysis. J Am Board Fam Med 2023; 36:175. doi:10.3122/jabfm.2022.220099r1
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- JR Curtis et al. Comparative effectiveness of denosumab vs alendronate among postmenopausal women with osteoporosis. J Bone Miner Res 2024 May 16 (epub). doi:10.1093/jbmr/zjae079
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- SR Cummings et al. Vertebral fractures after discontinuation of denosumab: a post hoc analysis of the randomized placebo-controlled FREEDOM trial and its extension. J Bone Miner Res 2018; 33:190. doi:10.1002/jbmr.3337
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- In brief: Severe hypocalcemia with denosumab (Prolia) in chronic kidney disease. Med Lett Drugs Ther 2024; 66:40.
- JH Krege et al. Teriparatide and osteosarcoma risk: history, science, elimination of boxed warning, and other label updates. JBMR Plus 2022; 6:e10665. doi:10.1002/jbm4.10665
- DL Kendler et al. Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet 2018; 391:230. doi:10.1016/s0140-6736(17)32137-2
- JS Finkelstein et al. Effects of teriparatide retreatment in osteoporotic men and women. J Clin Endocrinol Metab 2009; 94:2495. doi:10.1210/jc.2009-0154
- Abaloparatide (Tymlos) for postmenopausal osteoporosis. Med Lett Drugs Ther 2017; 59:97.
- PD Miller et al. Bone mineral density response rates are greater in patients treated with abaloparatide compared with those treated with placebo or teriparatide: results from the ACTIVE phase 3 trial. Bone 2019; 120:137. doi:10.1016/j.bone.2018.10.015
- A Gilsenan et al. Teriparatide did not increase adult osteosarcoma incidence in a 15-year US postmarketing surveillance study. J Bone Miner Res 2021; 36:244. doi:10.1002/jbmr.4188
- PD Miller et al. Effect of abaloparatide vs. placebo on new vertebral fractures in postmenopausal women with osteoporosis: a randomized clinical trial. JAMA 2016; 316:722. doi:10.1001/jama.2016.11136
- KE Ensrud et al. Effects of raloxifene on fracture risk in postmenopausal women: the raloxifene use for the heart trial. J Bone Miner Res 2008; 23:112. doi:10.1359/jbmr.070904
- A Gosset et al. Menopausal hormone therapy for the management of osteoporosis. Best Pract Res Clin Endocrinol Metab 2021; 35:101551. doi:10.1016/j.beem.2021.101551
- J Stevenson et al. Prevention and treatment of osteoporosis in women. Post Reprod Health 2023; 29:11. doi:10.1177/20533691221139902
- Conjugated estrogens/bazedoxifene (Duavee) for menopausal symptoms and prevention of osteoporosis. Med Lett Drugs Ther 2014; 56:33.
- JV Pinkerton et al. Effects of bazedoxifene/conjugated estrogens on the endometrium and bone: a randomized trial. J Clin Endocrinol Metab 2014; 99:E189. doi:10.1210/jc.2013-1707
- Romosozumab (Evenity) for postmenopausal osteoporosis. Med Lett Drugs Ther 2019; 61:83.
- D Shoback et al. Pharmacological management of osteoporosis in postmenopausal women: an Endocrine Society guideline update. J Clin Endocrinol Metab 2020; 105:587. doi:10.1210/clinem/dgaa048
- F Cosman et al. Romosozumab treatment in postmenopausal women with osteoporosis. N Engl J Med 2016; 375:1532. doi:10.1056/nejmoa1607948
- KG Saag et al. Romosozumab or alendronate for fracture prevention in women with osteoporosis. N Engl J Med 2017; 377:1417. doi:10.1056/nejmoa1708322
- BL Langdahl et al. Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial. Lancet 2017; 390:1585. doi:10.1016/s0140-6736(17)31613-6
- A Knopp-Sihota et al. Calcitonin for treating acute and chronic pain of recent and remote osteoporotic vertebral compression fractures: a systematic review and metaanalysis. Osteoporos Int 2012; 23:17. doi:10.1007/s00198-011-1676-0
- In brief: Cancer risk with salmon calcitonin. Med Lett Drugs Ther 2013; 55:29.
- G Wells et al. Does salmon calcitonin cause cancer? A review and meta-analysis. Osteoporos Int 2016; 27:13. doi:10.1007/s00198-015-3339-z
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