Matching articles for "glargine"

Drugs for Type 2 Diabetes

   
The Medical Letter on Drugs and Therapeutics • November 14, 2022;  (Issue 1663)
Diet, exercise, and weight loss can improve glycemic control, but almost all patients with type 2 diabetes require antihyperglycemic drug therapy. Treating to a target A1C of...
Diet, exercise, and weight loss can improve glycemic control, but almost all patients with type 2 diabetes require antihyperglycemic drug therapy. Treating to a target A1C of <7% while minimizing hypoglycemia is recommended to prevent microvascular complications of diabetes (retinopathy, nephropathy, and neuropathy). An A1C target of <8% may be appropriate for some older patients.
Med Lett Drugs Ther. 2022 Nov 14;64(1663):177-84 | Show Full IntroductionHide Full Introduction

Tirzepatide (Mounjaro) for Type 2 Diabetes

   
The Medical Letter on Drugs and Therapeutics • July 11, 2022;  (Issue 1654)
The FDA has approved tirzepatide (Mounjaro – Lilly), a peptide hormone with activity at both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, to improve...
The FDA has approved tirzepatide (Mounjaro – Lilly), a peptide hormone with activity at both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, to improve glycemic control in adults with type 2 diabetes. Tirzepatide, which is injected subcutaneously once weekly, is the first dual GIP/GLP-1 receptor agonist to become available in the US. Selective GIP receptor agonists are not available in the US; GLP-1 receptor agonists have been available for years.
Med Lett Drugs Ther. 2022 Jul 11;64(1654):105-7 | Show Full IntroductionHide Full Introduction

In Brief: Semglee - Insulin Glargine Interchangeable with Lantus

   
The Medical Letter on Drugs and Therapeutics • October 4, 2021;  (Issue 1634)
Insulin glargine-yfgn (Semglee – Viatris), a follow-on insulin glargine product, has now received interchangeability status with the reference product Lantus from the FDA. It is the first biosimilar...
Insulin glargine-yfgn (Semglee – Viatris), a follow-on insulin glargine product, has now received interchangeability status with the reference product Lantus from the FDA. It is the first biosimilar insulin product to receive this designation in the US. Now a pharmacist can substitute Semglee for Lantus as a lower-cost alternative without permission from the prescriber.
Med Lett Drugs Ther. 2021 Oct 4;63(1634):159-60 | Show Full IntroductionHide Full Introduction

In Brief: Semglee - A New Insulin Glargine for Diabetes

   
The Medical Letter on Drugs and Therapeutics • January 25, 2021;  (Issue 1616)
The FDA has approved Semglee (Mylan), an insulin glargine product similar to Lantus, for treatment of type 1 diabetes in children and adults and type 2 diabetes in adults. Semglee is the second...
The FDA has approved Semglee (Mylan), an insulin glargine product similar to Lantus, for treatment of type 1 diabetes in children and adults and type 2 diabetes in adults. Semglee is the second "follow-on" insulin glargine product to become available in the US; Basaglar, which is also similar to Lantus, was the first. Lantus is a recombinant analog of human insulin that forms microprecipitates in subcutaneous tissue, prolonging its duration of action to a mean of about 24 hours with no pronounced peak effect.
Med Lett Drugs Ther. 2021 Jan 25;63(1616):14-5 | Show Full IntroductionHide Full Introduction

Drugs for Type 2 Diabetes

   
The Medical Letter on Drugs and Therapeutics • November 4, 2019;  (Issue 1584)
Diet, exercise, and weight loss can improve glycemic control, but almost all patients with type 2 diabetes eventually require drug therapy. Treating to a glycated hemoglobin (A1C) concentration of...
Diet, exercise, and weight loss can improve glycemic control, but almost all patients with type 2 diabetes eventually require drug therapy. Treating to a glycated hemoglobin (A1C) concentration of <7% can prevent microvascular complications (retinopathy, nephropathy, and neuropathy), but whether it prevents macrovascular complications and death is unclear. An A1C target of <8% may be appropriate for older patients and those with underlying cardiovascular disease (CVD), a history of severe hypoglycemia, diabetes-related complications, a limited life expectancy, or a long duration of disease.
Med Lett Drugs Ther. 2019 Nov 4;61(1584):169-78 | Show Full IntroductionHide Full Introduction

Insulins for Type 2 Diabetes

   
The Medical Letter on Drugs and Therapeutics • May 6, 2019;  (Issue 1571)
The goal of drug therapy for type 2 diabetes is to achieve and maintain a near-normal glycated hemoglobin (A1C) concentration without inducing hypoglycemia; for most patients, the target A1C is...
The goal of drug therapy for type 2 diabetes is to achieve and maintain a near-normal glycated hemoglobin (A1C) concentration without inducing hypoglycemia; for most patients, the target A1C is <7%. Metformin is the preferred first-line treatment, but most patients with type 2 diabetes eventually require multidrug therapy and/or insulin to achieve glycemic control.
Med Lett Drugs Ther. 2019 May 6;61(1571):65-8 | Show Full IntroductionHide Full Introduction

Expanded Table: Some Available Insulins for Type 2 Diabetes (online only)

   
The Medical Letter on Drugs and Therapeutics • May 6, 2019;  (Issue 1571)
...
View the Expanded Table: Some Available Insulins
Med Lett Drugs Ther. 2019 May 6;61(1571):e73-7 | Show Full IntroductionHide Full Introduction

Semaglutide (Ozempic) - Another Injectable GLP-1 Receptor Agonist for Type 2 Diabetes

   
The Medical Letter on Drugs and Therapeutics • January 29, 2018;  (Issue 1539)
The FDA has approved semaglutide (Ozempic – Novo Nordisk), a long-acting injectable GLP-1 (glucagon-like peptide-1) receptor agonist, for once-weekly treatment of adults with type 2 diabetes. It is the...
The FDA has approved semaglutide (Ozempic – Novo Nordisk), a long-acting injectable GLP-1 (glucagon-like peptide-1) receptor agonist, for once-weekly treatment of adults with type 2 diabetes. It is the sixth GLP-1 receptor agonist to be approved in the US.
Med Lett Drugs Ther. 2018 Jan 29;60(1539):19-21 | Show Full IntroductionHide Full Introduction

Fiasp - Another Insulin Aspart Formulation for Diabetes

   
The Medical Letter on Drugs and Therapeutics • January 1, 2018;  (Issue 1537)
The FDA has approved Fiasp (Novo Nordisk), a new formulation of insulin aspart, to improve glycemic control in adults with diabetes. Fiasp is described by the manufacturer as faster-acting than...
The FDA has approved Fiasp (Novo Nordisk), a new formulation of insulin aspart, to improve glycemic control in adults with diabetes. Fiasp is described by the manufacturer as faster-acting than conventional insulin aspart (Novolog).
Med Lett Drugs Ther. 2018 Jan 1;60(1537):6-7 | Show Full IntroductionHide Full Introduction

Insulin Degludec/Liraglutide (Xultophy 100/3.6) for Type 2 Diabetes

   
The Medical Letter on Drugs and Therapeutics • September 11, 2017;  (Issue 1529)
The FDA has approved Xultophy 100/3.6 (Novo Nordisk), a fixed-ratio combination of insulin degludec and the GLP-1 (glucagon-like peptide-1) receptor agonist liraglutide, for once-daily treatment of adults...
The FDA has approved Xultophy 100/3.6 (Novo Nordisk), a fixed-ratio combination of insulin degludec and the GLP-1 (glucagon-like peptide-1) receptor agonist liraglutide, for once-daily treatment of adults with type 2 diabetes inadequately controlled on basal insulin (<50 units daily) or liraglutide (≤1.8 mg daily).
Med Lett Drugs Ther. 2017 Sep 11;59(1529):147-9 | Show Full IntroductionHide Full Introduction

Cardiovascular Effects of Some Antidiabetic Drugs

   
The Medical Letter on Drugs and Therapeutics • August 14, 2017;  (Issue 1527)
For many years, the goal of drug therapy for most patients with type 2 diabetes has been to achieve and maintain an A1C of...
For many years, the goal of drug therapy for most patients with type 2 diabetes has been to achieve and maintain an A1C of <7%. Achieving that goal can prevent microvascular complications (diabetic retinopathy, nephropathy, neuropathy), but whether it prevents macrovascular complications (myocardial infarction [MI], stroke) has been less clear. The FDA now requires that cardiovascular safety studies be performed for all new drugs for type 2 diabetes.1 Recent findings that some of the newer second-line drugs for type 2 diabetes have cardiovascular benefits have led to new interest in the cardiovascular efficacy and safety of all antidiabetic drugs.
Med Lett Drugs Ther. 2017 Aug 14;59(1527):136-8 | Show Full IntroductionHide Full Introduction

Prescription Drug Prices in the US

   
The Medical Letter on Drugs and Therapeutics • May 22, 2017;  (Issue 1521)
Per capita spending on prescription drugs in the US is higher than in other industrialized nations,...
Per capita spending on prescription drugs in the US is higher than in other industrialized nations, including Canada.
Med Lett Drugs Ther. 2017 May 22;59(1521):81-3 | Show Full IntroductionHide Full Introduction

Lixisenatide for Type 2 Diabetes

   
The Medical Letter on Drugs and Therapeutics • January 30, 2017;  (Issue 1513)
The FDA has approved lixisenatide (Sanofi), a short-acting injectable GLP-1 (glucagon-like peptide-1) receptor agonist, for once-daily treatment of adults with type 2 diabetes, both alone (Adlyxin) and in...
The FDA has approved lixisenatide (Sanofi), a short-acting injectable GLP-1 (glucagon-like peptide-1) receptor agonist, for once-daily treatment of adults with type 2 diabetes, both alone (Adlyxin) and in a fixed-ratio combination with insulin glargine (Soliqua 100/33). Lixisenatide has been available since 2013 in many other countries as Lyxumia. It is the fifth GLP-1 receptor agonist to be approved in the US.
Med Lett Drugs Ther. 2017 Jan 30;59(1513):19-21 | Show Full IntroductionHide Full Introduction

Inflectra - An Infliximab Biosimilar

   
The Medical Letter on Drugs and Therapeutics • January 30, 2017;  (Issue 1513)
The FDA has approved infliximab-dyyb (Inflectra – Pfizer; marketed as Remsima in some countries), as a biosimilar of the TNF inhibitor infliximab (Remicade). Infliximab-dyyb was approved in the European...
The FDA has approved infliximab-dyyb (Inflectra – Pfizer; marketed as Remsima in some countries), as a biosimilar of the TNF inhibitor infliximab (Remicade). Infliximab-dyyb was approved in the European Union (EU) in 2013 and in Canada in 2014. It is the second biosimilar to be approved by the FDA. Filgastrim-sndz (Zarxio), a recombinant human granulocyte colony-stimulating factor, was the first.
Med Lett Drugs Ther. 2017 Jan 30;59(1513):23-5 | Show Full IntroductionHide Full Introduction

Another Insulin Glargine (Basaglar) for Diabetes

   
The Medical Letter on Drugs and Therapeutics • January 2, 2017;  (Issue 1511)
The FDA has approved Basaglar (Lilly/Boehringer Ingelheim), a "follow-on" 100 units/mL insulin glargine product similar to Lantus (Sanofi), which recently went off patent. A 300 units/mL formulation of...
The FDA has approved Basaglar (Lilly/Boehringer Ingelheim), a "follow-on" 100 units/mL insulin glargine product similar to Lantus (Sanofi), which recently went off patent. A 300 units/mL formulation of insulin glargine (Toujeo) was approved in 2015.
Med Lett Drugs Ther. 2017 Jan 2;59(1511):3-4 | Show Full IntroductionHide Full Introduction

Insulin Degludec (Tresiba) - A New Long-Acting Insulin for Diabetes

   
The Medical Letter on Drugs and Therapeutics • December 7, 2015;  (Issue 1483)
The FDA has approved insulin degludec (Tresiba – Novo Nordisk) for treatment of adults with type 1 or type 2 diabetes. Insulin degludec is the third long-acting human insulin analog to be approved by...
The FDA has approved insulin degludec (Tresiba – Novo Nordisk) for treatment of adults with type 1 or type 2 diabetes. Insulin degludec is the third long-acting human insulin analog to be approved by the FDA; insulin detemir (Levemir) and insulin glargine (Lantus, Toujeo) were approved earlier.
Med Lett Drugs Ther. 2015 Dec 7;57(1483):163-4 | Show Full IntroductionHide Full Introduction

Canagliflozin (Invokana) for Type 2 Diabetes

   
The Medical Letter on Drugs and Therapeutics • May 13, 2013;  (Issue 1416)
Canagliflozin (kan" a gli floe' zin; Invokana – Janssen), a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has been approved by the FDA for oral treatment of type 2...
Canagliflozin (kan" a gli floe' zin; Invokana – Janssen), a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has been approved by the FDA for oral treatment of type 2 diabetes.
Med Lett Drugs Ther. 2013 May 13;55(1416):37-9 | Show Full IntroductionHide Full Introduction

What Comes After Metformin for Type 2 Diabetes?

   
The Medical Letter on Drugs and Therapeutics • July 23, 2012;  (Issue 1395)
Most experts agree that lifestyle modifications and metformin (Glucophage, and others) should be used first to treat patients with type 2 diabetes. If metformin alone fails to control hyperglycemia, there...
Most experts agree that lifestyle modifications and metformin (Glucophage, and others) should be used first to treat patients with type 2 diabetes. If metformin alone fails to control hyperglycemia, there is no general agreement on which drug should be added next. A recent article in The Medical Letter offered some support for a sulfonylurea. Three recent trials published in The Lancet favored the long-acting basal insulin glargine, the glucagon-like peptide (GLP-1) analog exenatide, and the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin, respectively. Some of the advantages and disadvantages of these and other available agents are listed in Table 1 on the opposite page.
Med Lett Drugs Ther. 2012 Jul 23;54(1395):58-9 | Show Full IntroductionHide Full Introduction

Insulin Glargine (Lantus) and Cancer Risk

   
The Medical Letter on Drugs and Therapeutics • August 24, 2009;  (Issue 1319)
Several large European observational studies published on-line this summer have raised questions about whether use of insulin glargine increases the risk of...
Several large European observational studies published on-line this summer have raised questions about whether use of insulin glargine increases the risk of cancer.
Med Lett Drugs Ther. 2009 Aug 24;51(1319):67-8 | Show Full IntroductionHide Full Introduction

Drugs for Type 2 Diabetes

   
The Medical Letter on Drugs and Therapeutics • July 1, 2008;  (Issue 71)
The development of hyperglycemia in type 2 diabetes results from a combination of metabolic abnormalities including insulin resistance, diminished insulin secretion and excess hepatic glucose production. Diet,...
The development of hyperglycemia in type 2 diabetes results from a combination of metabolic abnormalities including insulin resistance, diminished insulin secretion and excess hepatic glucose production. Diet, exercise and weight loss are helpful in improving glucose control, but most patients ultimately require drug therapy.
Treat Guidel Med Lett. 2008 Jul;6(71):47-6 | Show Full IntroductionHide Full Introduction

Insulin Glulisine (Apidra) -- A New Rapid-Acting Insulin

   
The Medical Letter on Drugs and Therapeutics • April 24, 2006;  (Issue 1233)
Insulin glulisine (Apidra - Sanofi Aventis) is the third rapid-acting insulin analog to be marketed in the US, following insulin lispro (Humalog) and insulin aspart (Novolog). All three have a more rapid onset...
Insulin glulisine (Apidra - Sanofi Aventis) is the third rapid-acting insulin analog to be marketed in the US, following insulin lispro (Humalog) and insulin aspart (Novolog). All three have a more rapid onset and shorter duration of action than regular human insulin. Rapid-acting insulin analogs are generally taken immediately before meals and are usually combined with a long-acting basal insulin.
Med Lett Drugs Ther. 2006 Apr 24;48(1233):33-4 | Show Full IntroductionHide Full Introduction

Drugs for Diabetes

   
The Medical Letter on Drugs and Therapeutics • August 1, 2005;  (Issue 36)
The development of hyperglycemia in type 2 diabetes results from a combination of metabolic abnormalities including insulin resistance, excess hepatic glucose production and diminished insulin secretion. In...
The development of hyperglycemia in type 2 diabetes results from a combination of metabolic abnormalities including insulin resistance, excess hepatic glucose production and diminished insulin secretion. In many patients, diet and regular exercise can improve glucose control. Most drugs currently available for management of type 2 diabetes increase insulin supply (sulfonylureas, other secretagogues and insulin itself), decrease insulin resistance (thiazolidinediones) or improve the effectiveness of insulin (biguanides). Alpha-glucosidase inhibitors reduce the rate of glucose absorption. Newer agents such as pramlintide (Symlin) and exenatide (Byetta) have multiple effects to increase satiety and reduce postprandial hyperglycemia.
Treat Guidel Med Lett. 2005 Aug;3(36):57-62 | Show Full IntroductionHide Full Introduction

Drugs for Diabetes

   
The Medical Letter on Drugs and Therapeutics • September 1, 2002;  (Issue 1)
The development of hyperglycemia in type 2 diabetes results from a combination of metabolic abnormalities including insulin resistance, excess hepatic glucose production and diminished insulin secretion. Most...
The development of hyperglycemia in type 2 diabetes results from a combination of metabolic abnormalities including insulin resistance, excess hepatic glucose production and diminished insulin secretion. Most drugs currently available for management of type 2 diabetes fall into 2 categories: those that increase insulin supply (sulfonylureas, other secretagogues and insulin itself) and those that decrease insulin resistance or improve its effectiveness (biguanides, thiazolidinediones). Alpha-glucosidase inhibitors reduce the rate of glucose absorption.
Treat Guidel Med Lett. 2002 Sep;0(1):1-6 | Show Full IntroductionHide Full Introduction