MCC — MCC is a rare, aggressive neuroendocrine carcinoma of the skin. It is more common in men, particularly elderly, fair-skinned men with chronic sun exposure.1

MECHANISM OF ACTION — Binding of PD-L1 and PD-L2 to PD-1 on T cells suppresses T-cell proliferation and cytokine production. Retifanlimab binds to PD-1 on T cells, blocking its interaction with PD-L1 and PD-L2 and restoring T cell antitumor immune responses.

CLINICAL STUDIES — FDA approval of retifanlimab was based on the results of a single-arm trial (PODIUM-201) in 65 patients with metastatic or recurrent locally advanced MCC who had not received prior systemic therapy for advanced disease. Patients received retifanlimab 500 mg IV once every 4 weeks for up to 2 years. At the time of the primary efficacy analysis, about 42% of patients had discontinued treatment. The objective response rate was 46.2%, of which 12.3% were complete responses.2 About 76% of patients who achieved a response had a response of ≥6 months and 62% had a response of ≥12 months.

ADVERSE EFFECTS — Retifanlimab can cause fatigue, musculoskeletal pain, pruritus, diarrhea, rash, pyrexia, and nausea. Infusion-related reactions and severe and fatal immune-mediated reactions, including pneumonitis, colitis, hepatitis, endocrinopathies, and nephritis with renal dysfunction, can occur. Liver enzyme levels, serum creatinine levels, and thyroid function should be assessed before starting treatment and periodically during treatment. Potentially fatal complications can occur in patients who receive allogeneic hematopoietic stem cell transplantation (HSCT) before or after being treated with a PD-1/PD-L1 blocking antibody.

PREGNANCY AND LACTATION — Inhibition of the PD-1/PD-L1 pathway can result in immune-mediated rejection of the developing fetus and fetal death. Women of reproductive potential should use effective contraception during treatment with retifanlimab and for 4 months after the last dose. Women should not breastfeed during treatment with retifanlimab and for 4 months after the last dose.

DOSAGE, ADMINISTRATION, AND COST — Zynyz is supplied in 500 mg/20 mL single-dose vials. The recommended dosage is 500 mg administered intravenously over 30 minutes every 4 weeks until disease progression or unacceptable toxicity occurs or for up to 24 months. The label contains dosage adjustments that should be made if adverse effects occur. The cost of Zynyz is not yet available.