Melatonin for Insomnia in Children
Melatonin for Insomnia in Children
June 29, 2020 (Issue: 1601)
Over-the-counter products containing melatonin are
widely used as sleep aids in children and adults.
- S Tordjman et al. Melatonin: pharmacology, functions, and therapeutic benefits. Curr Neuropharmacol 2017; 15:434.
- LAE Erland and PK Saxena. Melatonin natural health products and supplements: presence of serotonin and significant variability of melatonin content. J Clin Sleep Med 2017; 13:275.
- KA Carter et al. Common sleep disorders in children. Am Fam Physician 2014; 89:368.
- AW Buckley et al. Practice guideline: treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology. Neurology 2020; 94:392.
- NL Phillips et al. Behavioral interventions for sleep disturbances in children with neurological and neurodevelopmental disorders: a systematic review and meta-analysis of randomized controlled trials. Sleep 2020 March 12 (epub).
- MG Smits et al. Melatonin for chronic sleep onset insomnia in children: a randomized placebo-controlled trial. J Child Neurol 2001; 16:86.
- MS McDonagh et al. Pharmacologic treatments for sleep disorders in children: a systematic review. J Child Neurol 2019; 34:237.
- P Gringras et al. Efficacy and safety of pediatric prolonged-release melatonin for insomnia in children with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry 2017; 56:948.
- A Maras et al. Long-term efficacy and safety of pediatric prolonged-release melatonin for insomnia in children with autism spectrum disorder. J Child Adolesc Psychopharmacol 2018; 28:699.
- BA Malow et al. Sleep, growth, and puberty after 2 years of prolonged-release melatonin in children with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry 2020 Jan 23 (epub).
- A Boafo et al. Could long-term administration of melatonin to prepubertal children affect timing of puberty? A clinician's perspective. Nat Sci Sleep 2019; 11:1.
- TC Zwart et al. Long-term melatonin therapy for adolescents and young adults with chronic sleep onset insomnia and late melatonin onset: evaluation of sleep quality, chronotype, and lifestyle factors compared to age-related randomly selected population cohorts. Healthcare (Basel) 2018; 6:23.
- Inhibitors and inducers of CYP enzymes and P-glycoprotein. Med Lett Drugs Ther 2019 November 6 (epub). Available at medicalletter.org/downloads/CYP_PGP_Tables.pdf.
- AB Dollins et al. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci USA 1994; 91:1824.
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