Drugs for Epilepsy
February 1, 2013 (Issue: 126)
Treatment of epilepsy should begin with a single
drug, increasing the dosage gradually until seizures
are controlled or adverse effects become unacceptable.
If seizures persist, expert clinicians generally
prescribe at least one and sometimes a...more
1. E Perucca and T Tomson. The pharmacological treatment of epilepsy in adults. Lancet Neurol 2011; 10:446.
2. WH Chung et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature 2004; 428:486.
3. P Chen et al. Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. N Engl J Med 2011; 364:1126.
4. Clobazam (Onfi) for Lennox-Gastaut Syndrome. Med Lett Drugs Ther 2012; 54:18.
5. EP Vining. Ethosuximide in childhood absence epilepsy - older and better. N Engl J Med 2010; 362:843.
6. Ezogabine (Potiga) for epilepsy. Med Lett Drugs Ther 2012; 54:65.
7. Gabapentin encarbil (Horizant) for restless legs syndrome. Med Lett Drugs Ther 2011; 53:70.
8. Lacosamide for epilepsy. Med Lett Drugs Ther 2009; 51:50.
9. AJ Rowan et al. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology 2005; 64:1868.
10. TA Glauser et al. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med 2010; 362:790.
11. EC De Los Reyes. Levetiracetam in the treatment of Lennox-Gastaut syndrome. Pediatric Neurol 2004; 30:254.
12. J Cavitt and M Privitera. Levetiracetam induces a rapid and sustained reduction of generalized spike-wave and clinical absence. Arch Neurol 2004; 61:1604.
13. GL Krauss et al. Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures. Neurology 2012; 78:1408.
14. JA French et al. Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304. Neurology 2012; 79:589.
15. JA French et al. Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: Results of randomized global phase III study 305. Epilepsia 2012 Aug 20 (epub).
16. Pregabalin (Lyrica) for neuropathic pain and epilepsy. Med Lett Drugs Ther 2005; 47:75.
17. Pregabalin (Lyrica) for fibromyalgia. Med Lett Drugs Ther 2007; 49:77.
18. Rufinamide (Banzel) for epilepsy. Med Lett Drugs Ther 2009; 51:18.
19. G Kluger et al. Adjunctive rufinamide in Lennox-Gastaut syndrome: a long-term, open-label extension study. Acta Neurol Scand 2010; 122:202.
20. V Biton et al. Arandomized, double-blind, placebo-controlled, parallel-group study of rufinamide as adjunctive therapy for refractory partial-onset seizures. Epilepsia 2011; 52:234.
21. Topiramate (Topamax) for prevention of migraine. Med Lett Drugs Ther 2005; 47:9.
22. Two new drugs for weight loss. Med Lett Drugs Ther 2012; 54:69.
23. Vigabatrin (Sabril) for epilepsy. Med Lett Drugs Ther 2010; 52:14.
24. SE Mohammadianenejad et al. Zonisamide versus topiramate in migraine prophylaxis: a double-blind randomized clinical trial. Clin Neuropharmacol 2011; 34:174.
25. KM Gadde et al. Zonisamide for weight reduction in obese adults: a 1-year randomized controlled trial. Arch Intern Med 2012; 172:1557.
26. CM Flowers et al. Seizure activity and off-label use of tiagabine. N Engl J Med 2006; 354:773.
27. C O’Dell et al. Rectal diazepam gel in the home management of seizures in children. Pediatr Neurol 2005; 33:166.
28. E Patorno et al. Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death. JAMA 2010; 303:1401.
29. A Arana et al. Suicide-related events in patients treated with antiepileptic drugs. N Engl J Med 2010; 363:542.
30. DS Reddy. Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives. Expert Rev Clin Pharmacol 2010; 3:183.
31. CL Harden et al. Practice parameter update: management issues for women with epilepsy–focus on pregnancy (an evidence-based review): teratogenesis and perinatal outcomes: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 2009; 73:133.
32. J Jentink et al. Valproic acid monotherapy in pregnancy and major congenital malformations. N Engl J Med 2010; 362:2185.
33. KJ Meador et al. Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 years. Neurology 2012; 78:1207.
34. D Mølgaard-Nielsen and A Hviid. Newer-generation antiepileptic drugs and the risk of major birth defects. JAMA 2011; 305:1996.
35. S Hernández-Diaz et al. Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012; 78:1692.
36. PB Pennell et al. Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency. Neurology 2008; 70:2130.
37. CL Harden et al. Practice parameter update: management issues for women with epilepsy–focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology 2009; 73:142.
38. AS Kesselheim et al. Seizure outcomes following the use of generic versus brand-name antiepileptic drugs: a systematic review and meta-analysis. Drugs 2010; 70:605.
39. GL Krauss et al. Assessing bioequivalence of generic antiepilepsy drugs. Ann Neurol 2011; 70:221.
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